Elderberry for the Flu
The Black Elderberry grows in British Columbia |
What if there was proven remedy that was safe, tastes good
and will reduce your flu symptoms by 90% within three days? What if this
natural medicine is safe for children? What if
it works for other viruses? Let’s find out the interesting facts about
Black Elderberry: Sambucus nigra.
The ripe berries of Sambucus nigra (Black Elderberry) have
been shown to effectively control the growth of the H5N1 Avian flu strain. A study in Israel, published in the Journal
of Alternative and Complementary Medicine, showed 20% of patients taking
elderberry extracts had dramatic improvements in symptoms including fever,
muscle pains and cough. This increased to an improvement in 73% of patients by the second
day and 90% by the third day. Compared to the placebo group, in which only 16%
improved after two days, there was a clinically significant improvement in the
elderberry cohort.
There were two positive results: there was a greater percentage of the patients improving and the improvements manifested four days sooner. Children in the study took two tablespoonfuls daily and adults took four.
There were two positive results: there was a greater percentage of the patients improving and the improvements manifested four days sooner. Children in the study took two tablespoonfuls daily and adults took four.
Another randomized, double blind, placebo controlled study
in Norway showed a reduction of flu symptoms
by four days. This study concluded that elderberry extracts stimulate
the healthy immune system by increasing
the production of immune system mediator cytokines.
The ripe berries are used, devoid of twigs or branches |
The medicinal part of the plant is the ripe berries. It
contains several flavonoids, the most important ones being the anthocyanidins cyanidin-3-glucoside
and cyanidin-3-sambubioside. Elderberries are also rich in the bioflavonoids
rutin, isoquertin and hyperoside. The
anthocyanidins are quickly absorbed, showing significant plasma levels in
thirty minutes. Excretion is through the kidneys as glucoronide conjugates.
Mechanism of Action
The mechanism of action seems to be two fold. The first
mechanism is immunomodulation
through increased production of inflammatory response cytokines such as
interleukin and tumor necrosis factor. This implies that Elderberry is beneficial for immunosupressed patients, for example, someone undergoing chemotherapy. Patients with autoimmune conditions such as lupus, rheumatoid arthritis and psoriasis can also benefit from the properties of elderberry without worsening their condition. This is an important consideration when they get viral infections.
Immunomodulators are substances that regulate or modify the function of the immune system. Immunosuppressants inhibit the immune response and immunostimulants stimulate the immune response.It is unclear how immunomodulators work, but it is hypothesized that they act on certain points of the immune activation pathways. Cytokines present in the elderberry are natural immunomodulators. They have multiple interacting roles in the immune pathways.
Immunomodulators are substances that regulate or modify the function of the immune system. Immunosuppressants inhibit the immune response and immunostimulants stimulate the immune response.It is unclear how immunomodulators work, but it is hypothesized that they act on certain points of the immune activation pathways. Cytokines present in the elderberry are natural immunomodulators. They have multiple interacting roles in the immune pathways.
In a study in Israel in 1995, Elderberry
Extracts have also been shown to have antiviral effectiveness against several flu strains including human,
swine and avian strains. The extract is thought to inhibit both hemagglutinin
activity and viral cell replication.
A well designed berry pickers that separates the berries and branches |
Side Effects
Orally, elderberry extract is well tolerated. It is sweet and fruity tasting and is suitable
for children. The ripe berries are used
and the proper preparation involves removal of all twigs and branches. The raw and unripe fruit has been reported to
cause nausea, vomiting and diarrhea. Therefore, it is recommended that home
preparations of elderberry juice, extracts, wines or tinctures not be consumed in large quantities and cannot be used for
medicinal purposes.
Elderflower Tea: Used Differently
The flowers of the elderberry tree are used effectively for
sinusitis. There is insufficient reliable information about the effectiveness
of the elder flower for its other uses. The mechanism of action is from the
flavonoids lectin, rutin, choline tannin and lipophilic triterpinoids. It also
exerts antioxidant activity from sterol compound such as lupeol and
beta-sitosterol.
There have been no studies on the use of the elder flower in
influenza cases.
The elder flowers are often prepared in an extract or a tea.
Elderberry syrup can be served hot as a delicious tea |
References:
J Int Med Res. 2004
Mar-Apr;32(2):132-40
Randomized study of the
efficacy and safety of oral elderberry extract in the treatment of influenza A
and B virus infections.
Source
Department
of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J
Altern Complement Med. 1995 Winter;1(4):361-9
Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama.
Source
Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J Nutr. 2002 Jul;132(7):1865-71.
Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry.
Source
U.S. Department of Agriculture, Agriculture Research Service, Arkansas Children's Nutrition Center, Little Rock 72202, USA.
Herbal Medicine: Biomolecular and Clinical Aspects
By Iris F. F. Benzie, Sissi
Wachtel-Galor
Eur Cytokine Netw. 2001 Apr-Jun;12(2):290-6.
The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines.
Source
Immunology Laboratory for Tumor Diagnosis, Department of Oncology, Hadassah University Hospital, Jerusalem, Israel.